COAGULATION FACTOR V GENE MUTATION INCREASES THE RISK OF VENOUS THROMBOSIS IN BEHÇET'S DISEASE
Open Access
- 1 November 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 35 (11) , 1178-1180
- https://doi.org/10.1093/rheumatology/35.11.1178
Abstract
We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behçet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in 37.5% of the patients with a history of deep vein thrombosis (12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation (10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the development of venous thrombosis in BD.Keywords
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