Asymmetric Michael Reaction of α-Cyano Esters Catalyzed by Chiral Rh(I) Complexes with a New Optically Active Biphosphine Ligand
- 1 January 1997
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1 (01) , 119-120
- https://doi.org/10.1055/s-1997-712
Abstract
Asymmetric addition of 2-cyanoproprionates to methyl vinyl ketone in the presence of 1 mol% of chiral Rh(I) catalysts containing a novel chiral bisphosphine ligand ((R)-7,7'-bis(diphenylphosphinomethyl)-2,2'-dimethoxy-1,1'-binaphthyl) gave optically active Michael adducts in good yields with enantiomeric excesses up to 73% ee.Keywords
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