The use of lod scores for the determination of the order of loci on a chromosome
- 1 October 1975
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 39 (2) , 255-260
- https://doi.org/10.1111/j.1469-1809.1975.tb00127.x
Abstract
A method is given for calculating the probabilities of the possible gene orders for a group of syntenic loci using lod scores calculated for each pair of loci in the group. Applying it, we find the most probable gene order for the five loci on chromosome 1 to be PGM1; Rh; PGD; PEP-C; Fy. However, the probabilities for other orders such that Rh lies between PGM1 and PGD with PEP-C and Fy outside these three are of a similar order of magnitude and no firm conclusions can be given. The probability for other possible orders is negligible.Keywords
This publication has 6 references indexed in Scilit:
- Segregation of genetic markers in families with chromosome polymorphisms and structural rearrangements involving chromosome 1Annals of Human Genetics, 1974
- Linkage data on Rh, PGM1PGD, Peptidase C and Fy from family studiesAnnals of Human Genetics, 1973
- Demonstration of a sex difference in recombination fraction in the loose linkage, Rh and PGM1Annals of Human Genetics, 1972
- Assignment and map‐positioning of human loci using chromosomal variationAnnals of Human Genetics, 1971
- A note on the mean measurements of human chromosomesAnnals of Human Genetics, 1964
- THE ESTIMATION OF MAP DISTANCES FROM RECOMBINATION VALUESAnnals of Eugenics, 1943