ESTIMATION OF MUTATION-RATE FROM RARE PROTEIN VARIANTS
- 1 January 1977
- journal article
- research article
- Vol. 29 (3) , 225-232
Abstract
A method for estimating the mutation rate for protein loci from the number of rare alleles in the population is presented. Applying this method to Neel''s data from American Indians in South America and to Nozawa''s data from Jananese macaques, the mutation rate for electrophoretically detectable alleles is estimated to be (2 .apprx. 3) .times. 10-6/locus per generation. This estimate may not include many severely or substantially deleterious mutations.This publication has 18 references indexed in Scilit:
- A note on the sampling theory for infinite alleles and infinite sites modelsTheoretical Population Biology, 1974
- Albumin Yanomama‐2, a ‘private’ polymorphism of serum albuminAnnals of Human Genetics, 1974
- Regional Linguistic and Genetic Differences among Yanomama IndiansScience, 1974
- “Private” Genetic Variants and the Frequency of Mutation Among South American IndiansProceedings of the National Academy of Sciences, 1973
- A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite populationGenetics Research, 1973
- Additional data on the population distribution of human serum albumin genes; three new variantsAnnals of Human Genetics, 1973
- The sampling theory of selectively neutral allelesTheoretical Population Biology, 1972
- Pattern of neutral polymorphism in a geographically structured populationGenetics Research, 1971
- Theoretical foundation of population genetics at the molecular levelTheoretical Population Biology, 1971
- The frequency distribution of lethal chromosomes in finite populations.Proceedings of the National Academy of Sciences, 1968