Tissue Distribution and Storage Forms of Vitamin B12 Injected and Orally Administered to the Dog.
- 1 January 1963
- journal article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 112 (1) , 262-266
- https://doi.org/10.3181/00379727-112-28011
Abstract
1. The distribution of oral and intravenous Vit. B12 was determined simultaneously in dogs using vitamin preparations labeled respectively with cobalt-57 and cobalt-60. 2. Thirty-one days after administration, the ratio of Co57/Co60 was constant in all tissues, indicating the existence of a common pool for cobalamin and related compounds regardless of mode of administration. 3. Conversion of administered labeled Vit. B12 to a noncyano form was demonstrated by reverse isotope dilution analysis of livers. This is true regardless of mode of administration. 4. It is suggested that chemical changes in the vitamin account in part for the complex excretion pattern of labeled Vit. B12.Keywords
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