ACTION OF S-ADENOSYL-L-HOMOCYSTEINE ON THE METABOLISM OF DOPAMINE, NOREPINEPHRINE AND SEROTONIN IN RAT-BRAIN

  • 1 January 1979
    • journal article
    • research article
    • Vol. 240  (1) , 35-44
Abstract
S-Adenosylhomocysteine (SAH) (0.1-30 mg/kg i.p.) increased 3H-norepinephrine synthesis from 3H-Tyr in the rat brain stem and mid-brain, but did not alter its tissular level. SAH decreased both the serotonin level and the formation of 3H-serotonin from 3H-Trp and increased the formation of 3H-5-hydroxy-IAA. The effects began 1 h after administration and was still present 6 h later. Dopamine metabolism was not altered. A correlation between the hypnotic effect of SAH and the modification of cerebral monoamine metabolism was pointed out.