Prophylactic Treatment of Wilson's Disease

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Abstract
To the Editor: Recent exchanges in the journal on this topic deserve further comment because of the great need to explain the poor quality of most publications concerned with therapeutic research in humans. If ever there was an opportunity for the successful use of the case method of teaching, this is it.The paper by Sternlieb and Scheinberg (New Eng. J. Med. 278:352–359, 1968) certainly suggests that all asymptomatic siblings with Wilson's disease should be treated indefinitely with penicillamine. But their "controls" are a contrived after-thought, and it remains possible, although admittedly not probable, that their conclusion may be . . .

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