Radiation-induced DNA Strand Breaks in Deoxygenated Aqueous Solutions. The Formation of Altered Sugars as End Groups

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Abstract
Gamma irradiation of DNA in deoxygenated, N2O-saturated aqueous solution leads to 3 bound altered sugars present as end groups in broken DNA strands. These sugars are linked to the DNA by phosphoric acid ester bonds. The structures of the end groups of 2 of the sugars are given. The structure of the 3rd end group after dephosphorylation was also given. The formation of the first 2 bound sugars is explained by a mechanism postulated earlier for the formation of free altered sugars. Except for the phosphoric acid ester linkage, the free altered sugars have the same chemical structures as the bound altered sugars.