Brief Note Lymphocyte RNA Synthesis in Infectious Mononucleosis: The Response to Phytohemagglutinin in Vitro
Open Access
- 1 October 1966
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 28 (4) , 602-605
- https://doi.org/10.1182/blood.v28.4.602.602
Abstract
Circulating lymphocytes were isolated from normal individuals and from patients with IM. IM lymphocytes synthesized RNA at 10 times the rate of normal lymphocytes. A 1-hour exposure to PHA did not result in the stimulation of 4 to 30S RNA synthesis which occurs in a similarly treated normal lymphocyte. RNA synthesis in IM lymphocytes actually appeared to be depressed by this short exposure to PHA.Keywords
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