Length of Epstein-Barr Virus Termini as a Determinant of Epithelial Cell Clonal Emergence
Open Access
- 1 August 2003
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (15) , 8555-8561
- https://doi.org/10.1128/jvi.77.15.8555-8561.2003
Abstract
Reiterated terminal sequences of Epstein-Barr virus (EBV) DNA are numerically heterogeneous among infectious virions, providing a viral measure of clonality in infected cells. After in vitro infection, carcinoma cells bearing EBV episomes with fewer terminal repeats (TRs) proliferated faster. In single-cell clones, TR number varied inversely to the quantity of latent membrane protein 2A (LMP2A) transcripts whose unspliced precursors cross joined TRs. Thus, EBV clonality may reflect selection for a TR number that optimizes LMP2A-enhanced tumor progression, with infection occurring after epithelial cell transformation.Keywords
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