Mechanism of the Effect of Trypsin on Specific Hemagglutination with Incomplete Rh Antisera.

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Abstract
Summary Under conditions of trypsin treatment of RBC which produce specific agglutination by incomplete Rh antisera, the enzyme binds firmly to the cells. The enzymatically inactive DIP-trypsin binds to an even higher degree but fails to produce the serologic effect. Enzymatic assays of trypsin in RBC supernates support the concept of binding of enzyme to cells. Serial passage of RBC supernates and determination of their ability to produce the serologic effects are also in agreement. An hypothesis concerning thermodynamic considerations of the reaction is discussed.

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