The effect of a rat plasma high‐density lipoprotein subfraction on the synthesis of bile salts by rat hepatocyte monolayers

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Abstract
The effect of a rat high-density lipoprotein subfraction (HDL2) on the synthesis of bile salts by rat hepatocyte monolayers prepared from rats fed a diet containing cholestyramine, was investigated. The synthesis of bile salts as measured by radioimmunoassay of conjugated cholic, chenodeoxycholic and β-muricholic acids was significantly increased when hepatocytes were incubated with a physiological concentration (500 μg HDL, protein·ml−1) of HDL2

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