Severe anaphylactic shock due to repeated application of aprotinin in patients following intrathoracic aortic replacement
- 1 January 1993
- journal article
- case report
- Published by Oxford University Press (OUP) in European Journal of Cardio-Thoracic Surgery
- Vol. 7 (9) , 495-496
- https://doi.org/10.1016/1010-7940(93)90280-O
Abstract
Aprotinin is known to significantly reduce the incidence of perioperative bleeding complications in cardiac, thoracic and vascular surgery. Despite the wide use of this medication in other surgical fields,there are only a few reports of serious adverse side effects. In this paperwe report on two patients with severe anaphylactic shock due to repeatedadministration of aprotinin, who both required cardiopulmonaryresuscitation.Keywords
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