Proton transverse relaxation rate (R2) images of iron‐loaded liver tissuepping local tissue iron concentrations with MRI
Open Access
- 18 March 2003
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 49 (3) , 572-575
- https://doi.org/10.1002/mrm.10378
Abstract
Proton transverse relaxation rate (R2) imaging measurements were made on post mortem iron-loaded human liver tissue samples (both intact and dissected into approximately 1-cm cubes) from a single subject. Iron concentrations for the dissected samples as measured by atomic absorption spectrometry varied from 10.8 to 23.3 mg Fe.g−1 dry tissue. A significant linear correlation between the mean R2 and iron concentration of each sample was found (r = 0.95). In addition, regions of liver tissue with micronodular cirrhosis exhibited lower R2 values, corresponding to the displacement of iron by fibrotic septa. The cirrhotic tissue was clearly identified as a separate peak in the R2 distribution of the tissue. The relaxivity of the iron did not appear to depend on the microarchitecture of the tissue. Magn Reson Med 49:572–575, 2003.Keywords
This publication has 20 references indexed in Scilit:
- Theory of nonexponential NMR signal decay in liver with iron overload or superparamagnetic iron oxide particlesMagnetic Resonance in Medicine, 2002
- Quantification of Liver Iron Overload by T2 Quantitative Magnetic Resonance Imaging in ThalassemiaJournal of Pediatric Hematology/Oncology, 1999
- Variability in hepatic iron concentration measurement from needle-biopsy specimensJournal of Hepatology, 1996
- Assessment of liver iron overload by T2-Quantitative magnetic resonance imaging: Correlation of T2-QMRI measurements with serum ferritin concentration and histologic grading of siderosisMagnetic Resonance Imaging, 1995
- Uneven hepatic iron and phosphorus distribution in beta-thalassemiaJournal of Hepatology, 1995
- Liver iron quantification: Studies in aqueous iron solutions, iron overloaded rats, and patients with hereditary hemochromatosisMagnetic Resonance Imaging, 1994
- Precision, accuracy, and image plane uniformity in NMR relaxation time imaging on a 1.5 T whole-body MR imaging systemMagnetic Resonance Imaging, 1994
- Identification of patients with hereditary haemochromatosis by magnetic resonance imaging and spectroscopic relaxation time measurementsMagnetic Resonance Imaging, 1992
- Non‐invasive quantitation of liver iron‐overload by magnetic resonance imagingBritish Journal of Haematology, 1990
- Stoichiometry of magnesium and calcium ion binding to concanavalin ABiochemistry, 1983