Distribution of Azithromycin in Plasma and Tonsil Tissue after Repeated Oral Administration of 10 or 20 Milligrams per Kilogram in Pediatric Patients

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Abstract
Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribution of azithromycin, suggesting the achievement of enhanced therapeutic concentrations at infective sites of the upper respiratory tract.
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