Suppression induction in vivo by a T helper clone?

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Abstract
We have previously described a helper T cell clone which augments in vivo cytotoxic T cell responses when injected at 104 cells per mouse, but not at 105 per mouse (Crispe, I. N. et al., Immunology 1984. 52: 55.). To test whether this dose‐response relationship was due to the induction of suppression, naive syngeneic mice were injected with lo5 cloned T helper cells, and their spleen cells were subsequently assayed for suppressive activity in adoptive transfer experiments. Lymphocytes from such mice indeed suppressed an antigen‐specific cytotoxic response, but only in the presence of the same T helper cell clone freshly added at the time of adoptive transfer. On this basis we argue that the distinction between T helper cell activity and T suppressor‐inducer activity corresponds to differences in cell numbers, rather than to two separate cell lineages.