Are Homozygotes for HLA B27 More Susceptible to Ankylosing Spondylitis?

Publisher Website
Google Scholar
Abstract
To the Editor: A close association between HLA B27 and ankylosing spondylitis has been demonstrated in several studies.1 A family with two siblings affected with both ankylosing spondylitis and iritis and the third affected with iritis only, has been called to our attention. The parents (Fig. 1), of Jewish Polish origin, were first cousins, who died during the holocaust. The combination of parental consanguinity and the fact that all three siblings were affected suggested the possible homozygosity for HLA B27 derived from a common ancestor.Examination of the family revealed that the proposita (IV-4), 52 years of age, had . . .

This publication has 1 reference indexed in Scilit: