RELATION BETWEEN RENIN SUBSTRATE AND ACUTE PHASE PROTEINS

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Abstract
In adrenalectomized rats, renin substrate was, as previously found, extremely low in non‐substituted animals, markedly decreased in salt‐ substituted animals, but only slightly decreased in both salt‐ and DOCA‐substituted animals. After three of four injuries, known to increase acute phase proteins, there was also an adrenal‐dependent increase in renin substrate. A similar adrenal‐dependent increase in substrate was further found in 24‐hour uninephrectomized rats and in rats with ceased urine excretion, while the increase after binephrectomy is non‐adrenal‐dependent and thus not due to ceased urine excretion.

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