Selective effects of some 5-lipoxygenase inhibitors on synovial interleukin-1 (IL-1) production compared with IL-1 synthesis inhibitors
- 1 March 1993
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 39 (S1) , C186-C188
- https://doi.org/10.1007/bf01972761
Abstract
To determine the role of 5-LO regulation of IL-1 in synovial tissues, we examined the effects of 5-LO inhibitors compared with standard IL-1 synthesis inhibitors on IL-1 production by human synovial tissue explants from patients with inflammatory arthropathies. MK886, L-656,224, PF-5901, and tepoxalin all inhibited IL-1 production in concentrations up to 10 μM, whereas other 5-LO inhibitors (ICI-211,965, zileuton), as well as IL-1 synthesis inhibitors (IX-207,887, tenidap), were inactive. LT products, thus regulate IL-1 production and inhibition thereof is one strategy for inhibiting this cytokine.Keywords
This publication has 4 references indexed in Scilit:
- Absence of modulation of monokine production via endogenous cyclooxygenase or 5-lipoxygenase metabolites: MK-886 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), indomethacin, or arachidonate fail to alter immunoreactive interleukin-1β, or TNF-α production by human monocytes in vitroClinical Immunology and Immunopathology, 1991
- Inhibition of monokine release by IX 207–887Inflammation Research, 1990
- Simple, sensitive and specific bioassay of interleukin-1Journal of Immunological Methods, 1989
- Regulation of interleukin 1 production by mouse peritoneal macrophages. Effects of arachidonic acid metabolites, cyclic nucleotides, and interferons.Journal of Biological Chemistry, 1986