The problem of blood vessel anastomosis deserves important consideration in this war because (1) advances in the control of serious infection and the possible use of anticoagulants afford, for the first time in the history of wars, a basis for success; (2) the outstanding cause of the loss of limbs in this war will be damage to the blood supply. Vitallium is a nonirritating alloy suitable as a prosthesis for a vein graft bridging an artery or vein defect in a nonsuture method of vessel anastomosis using a single or double tube technic. Carefully controlled expts. on dogs showed that sulfathiazole by mouth contributes greatly to the success of delayed anastomoses of severed vessels in contaminated wounds. Sulfanilamide used in alternate wounds in a series of 77 anastomoses was of moderate but definite value. The nonsuture method was shown to be highly successful in anastomosing the small femoral arteries of dogs, even in contaminated wounds 24 hrs. after section of. the artery, and without the use of anticoagulants.