IGF-II and IGF-binding proteins increase dramatically during rabbit pregnancy

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Abstract
During pregnancy, changes in the IGF axis are associated with changes in maternal metabolism and nutrient repartitioning which are necessary to meet the demands of a growing conceptus. The aim of this study was to assess the IGF axis, maternal weight changes and food intake in female New Zealand White rabbits (n=7) prior to breeding (day 0) and serially throughout pregnancy until term (day 30-31). The total weight of the pregnant does progressively increased from 4·03±0·06 kg (mean ± s.e.m.) on day 0 to 4·47 ±0·07 kg on day 30 (Pad libitum, food intake did not change until day 29 when it decreased to approximately 50% of previous intake (PPPJournal of Endocrinology (1996) 148, 121–130

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