TISSUE DISTRIBUTION OF HIGH-DENSITY LIPOPROTEIN LABELED WITH RADIOIODINATED CHOLESTEROL

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 21  (9) , 852-858
Abstract
This preliminary study was undertaken to explore possible methods for enhancing the target organ specificity of radioiodinated cholesterol. 19-[125I]cholesterol (I*C) was rapidly incorporated and transported in high-density lipoproteins (HDL) following i.v. administration to rats, and thus behaved like cholesterol in this regard. Incorporation of I*C into HDL (I*C-HDL) before administration produced little changes in the tissue distribution profile except for a reduction in the amount of radioactivity appearing in the thyroid. This suggested that the lipoprotein carrier may have afforded protection from metabolic dehalogenation of I*C. When rats were pretreated with 4-aminopyrazolo-[3,4-d]-pyrimidine to drastically reduce the circulating lipoprotein levels, a 4-fold enhancement in adrenal uptake was observed following I*C-HDL administration. This finding was consistent with the current view that the rat adrenal contains high-affinity and saturable receptors for HDL.

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