ANTI-INFLAMMATORY ACTIVITY OF 2 NOVEL DERIVATIVES OF PREDNISOLONE

1 January 1980

journal article
research article

Vol. 27 (3) , 611-614

Abstract

The antiinflammatory activity of 2 new steroids synthesized by modifying the 17.beta.-ketol side chain of prednisolone to the glycolate and glyoxylate methyl esters was investigated in the carrageenan paw edema test in rats. The 2 ester derivatives retained antiinflammatory potency, nearly equivalent to that of the parent compound, when administered s.c. at the site of inflammation. The glyoxylate ester, when administered by systemic route, showed a weaker suppression of inflammation. The glycolate ester showed a resystemic route than when it was applied topically.

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