A rat model for monitoring homograft rejection of the lung.

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Abstract
KONDO, T., SHIONOZAKI, F., FUJIMURA, S., YAMAUCHI, A., HANDA, M., OKABE, T., SAITO, R., ICHINOSE, T., SHIRAISHI, Y. and NAKADA, T. A Rat Model for Monitoring Homograft Rejection of the Lung. Tohoku J. exp. Med., 1986, 149 (3), 323-328 - A new surgical procedure was devised for the experimental homograft of the lung. The pulmonary artery and vein and bronchus were anastomosed under the operation microscope using interrupted sutures in group W (30 outbred Wistar rats) and continuous sutures in group F (7 inbred F344/Ducrj Rats). Mean ischemia time during the operation was 95.3±10.3min in the group W and 55.6± 5.8 in group F. Eight out of 30 rats (27%) of group W and all rats of group F survived more than 24hr after the surgery. Pulmonary functions of grafted lungs were evaluated by serial x-rays and the perfusion ratio was 27.4±11.6% (mean± S.D.) in group W and 25.4±7.7% in group F. A patent opening of the hilar anastomosis in these rats was confirmed at autopsy. This model with continuous suture would be useful for the rat lung transplantation.

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