Graphical Model for Estimating Oral Bioavailability of Drugs in Humans and Other Species from Their Caco-2 Permeability and in Vitro Liver Enzyme Metabolic Stability Rates
- 20 December 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 45 (2) , 304-311
- https://doi.org/10.1021/jm010152k
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replicationJournal of Pharmaceutical Sciences, 1999
- Linear Correlation of the Fraction of Oral Dose Absorbed of 64 Drugs Between Humans and RatsPharmaceutical Research, 1998
- Managing the drug discovery/development interfaceDrug Discovery Today, 1997
- Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography–atmospheric pressure ionization tandem mass spectrometryJournal of Chromatography A, 1997
- Simultaneous Pharmacokinetic Screening of a Mixture of Compounds in the Dog Using API LC/MS/MS Analysis for Increased ThroughputJournal of Medicinal Chemistry, 1997
- Prediction of in vivo drug metabolism in the human liver from in vitro metabolism dataPharmacology & Therapeutics, 1997
- Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsAdvanced Drug Delivery Reviews, 1997
- Caco-2 monolayers in experimental and theoretical predictions of drug transportAdvanced Drug Delivery Reviews, 1996
- Pharmaceutical innovation by the seven UK‐owned pharmaceutical companies (1964‐1985).British Journal of Clinical Pharmacology, 1988