Synthesis of Optically Active Mandelic AcidviaMicrobial Oxidation of Racemic 1-Phenyl-l,2-ethanediol

1 January 1992

journal article
Published by Taylor & Francis in Bioscience, Biotechnology, and Biochemistry

Vol. 56 (8) , 1216-1220
https://doi.org/10.1271/bbb.56.1216

Abstract

Microorganisms that converted racemic 1-phenyl-1,2-ethanediol ((RS)-1) to optically active mandelic acid (2) were screened for, and Bordetella parapertussis KPPA 20005 was selected as the best strain. This bacterium accumulated 2.0 g/liter of (R)-2 (95% e.e.), along with a small amount of benzoylformic (3) and benzoic acid (4) starting from 5.0 g/liter of (RS)-1. Production of 3 and 4 were inhibited by adding the substrate together with 0.3 to 3.0% ethanol after growth for 2 days.

Keywords

MICROORGANISMS
RACEMIC
PHENYL
OPTICALLY ACTIVE
ACTIVE MANDELIC
MANDELIC ACID
CONVERTED
E.E

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