Oxygen Extraction Ratio: A Valid Indicator of Transfusion Need in Limited Coronary Vascular Reserve?

Abstract
We have described whole body oxygen (O2) extraction ratio (ER) as a reliable indicator of transfusion need in acute normovolemic anemia. In normal hearts, myocardial lactate production (–LACT), indicating anaerobic metabolism, does not occur until the ER >50% and Hct 50% remains a valid indicator of myocardial metabolism in anemia in the presence of limited coronary vascular reserve. The ER may be a useful guide to transfusion therapy.

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