Effect of Propylthiouracil on thein VivoDeiodination of Thyroxine Labeled with I131in Different Positions
- 1 December 1963
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 73 (6) , 744-747
- https://doi.org/10.1210/endo-73-6-744
Abstract
It has been found, using thyroidectomized, thyroxine-maintained rats, that the administration of propylthiouracil depresses the urinary excretions of iodide I131 when labeled L-thyroxine is injected previously. This decrease was found whether the hormone was labeled with I131 on the atoms of the phenolic ring, on those of the inner ring, or had been biosynthetically labeled. It is concluded that this thiouracil partially inhibits in vivo deiodination of thyroxine on both the phenolic and the inner ring.Keywords
This publication has 9 references indexed in Scilit:
- Effects of Propylthiouracil and Thiouracil on the Metabolism of Thyroxine and Several of Its Derivatives by Rat Kidney Slicesin Vitro1Endocrinology, 1962
- The effect of thiouracil on the metabolism of l-thyroxineBiochemical Journal, 1962
- Effect of Antithyroid Compounds on the Deiodination of Thyroxine in the RatEndocrinology, 1962
- Synthesis of Thyroxine by L-Amino Acid OxidaseEndocrinology, 1962
- THE EFFECT OF PROPYLTHIOURACIL, METHYLTHIOURACIL AND THIOURACIL ON THE PERIPHERAL METABOLISM OFl-THYROXINE IN THYROIDECTOMIZED,l-THYROXINE MAINTAINED RATSEndocrinology, 1961
- NORMAL I131L-THYROXINE METABOLISM IN THE PRESENCE OF POTASSIUM PERCHLORATE AND INTERRUPTED BY PROPYLTHIOURACIL1Endocrinology, 1960
- The Effect of Propylthiouracil on the Intrathyroid Metabolism of Iodine in RatsJournal of Biological Chemistry, 1960
- SELECTIVE INHIBITION OF THE CALORIGENIC ACTIVITIES OF CERTAIN THYROXINE ANALOGUES WITH CHRONIC THIOURACIL TREATMENT IN RATSEndocrinology, 1960
- Effect of Propylthiouracil on Degradation of I131-Labeled Thyroxine and TriiodothyronineAmerican Journal of Physiology-Legacy Content, 1956