A pharmacokinetic-pharmacodynamic disease model to predict in vivo antiviral activity of maraviroc

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Abstract
The viral dynamics of human immunodeficiency virus (HIV) infection has been widely studied and expressed as mathematic equations. For most of the current registered antiretroviral drugs, the pharmacokinetics is well characterized and some relationships with the viral load‐time profiles in plasma from HIV patients have been established. The integration of these models in a pharmacokinetic (PK)–pharmacodynamic (PD)–disease model can help toward a better understanding of the complexity of the interactions, as well as in the identification and clarification of the current model assumptions.

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