The effect of exogenous human ras and myc oncogenes in morphological differentiation of the rat pheochromocytoma pc12 cells
- 31 December 1988
- journal article
- research article
- Published by Wiley in International Journal of Developmental Neuroscience
- Vol. 7 (1) , 1-4
- https://doi.org/10.1016/0736-5748(89)90039-7
Abstract
An electroporation technique was employed to study the effect of oncogenes H/ras and c-myc after their short-term expression in the rat pheochromocytoma PC12 cells. It was found that within 6 days after electroporation the mutant T24 H-ras1 gene induced differentiation of PC12 cells whereas the c-myc blocked NGF-induced differentiation. The induction of differentiation by the T24 H-ras gene may suggest a physiological role of the ras gene in cell differentiation as well as in cell proliferation.This publication has 19 references indexed in Scilit:
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