Fructose metabolism in the intact animal

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Abstract
Two methods for the estimation of fructose in small amts. of blood, here descr., Avere used to investigate the fate of ingested and injected fructose in rabbits. The results obtained suggest that fructose stimulates the pancreas to secrete insulin. Insulin however has been found to have no effect on the rate of removal of fructose from the blood and it is therefore suggested that the metabolism of fructose takes place in 2 stages, the conversion, independently of insulin, of fructose into an unknown substance which is most probably glucose, the disposal of this substance under the influence of insulin.