The Effect of Ether and Laparotomy on Serum Prolactin Levels in Progesterone-Treated Intact and Ovariectomized Rats

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Abstract
Serum prolactin levels following ether anesthesia and laparotomy were measured in intact, cyclic rats which were injected daily, beginning on the first day of diestrus, with either oil or with 2 (P2) or 10 mg (P10) of progesterone. A single P2 or P10 injection affected neither the basal (decapitation) nor the ether-laparotomy serum prolactin level. Six days of treatment, however, reduced the ether-laparotomy-induced in-crease in the prolactin level, but had no effect on the basal level. Ovariectomized rats were also injected daily for 6 days, beginning on the 14th post-castration day, with either oil, P10,0.01 (E 0.01) or 0.25 µg (E 0.25) of free estradiol, or a combination of either E 0.01 + P10 or E 0.25 + P10. No significant differences in the serum prolactin levels were found between the rats killed by decapitation and those subjected to ether-laparotomy in any of these groups. Treatment with P10, however, significantly lowered the serum prolactin level although treatment with E 0.25 raised it. P10 treatment also reduced the estrogen (E O.25)-stimulated elevation in the prolactin level.

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