Relationship between alternate-day corticosteroid therapy and behavioral abnormalities

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Abstract
Patients (3) with inflammatory or immunologicall mediated disease manifested striking behavioral abnormalities in association with long-term alternate-day prednisone regimens. Differences in the abnormalities depended on the day that the patients received their drug: the symptoms that appeared on a treatment day were opposite those present on a day of no therapy. These symptoms were reminiscent of rapid mood cycling in some patients with manic-depressive affective disorder. The phenomenon was dose related and markedly diminished in 2 patients as the dosage of corticosteroid was decreased, despite the fact that the alternate-day regimen was continued.

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