The flexible genome
- 1 May 2001
- journal article
- research article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 2 (5) , 383-387
- https://doi.org/10.1038/35072018
Abstract
A principal assumption underlying contemporary genetic analysis is that the normal function of a gene can be inferred directly from its mutant phenotype. The interactivity among genes that is now being revealed calls this assumption into question and indicates that there might be considerable flexibility in the capacity of the genome to respond to diverse conditions. The reservoir for much of this flexibility resides in the nonspecificity and malleability of gene action.Keywords
This publication has 48 references indexed in Scilit:
- Contrasting Localizations of MALS/LIN-7 PDZ Proteins in Brain and Molecular Compensation in Knockout MicePublished by Elsevier ,2001
- Emergent Properties of Networks of Biological Signaling PathwaysScience, 1999
- Genome-wide expression monitoring in Saccharomyces cerevisiaeNature Biotechnology, 1997
- GENETIC CONTROL OF CELL FATE SPECIFICATION IN DROSOPHILA PERIPHERAL NERVOUS SYSTEMAnnual Review of Genetics, 1994
- Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinaseCell, 1991
- napts, a Mutation affecting sodium channel activity in Drosophila, Is an allele of mle a regulator of X chromosome transcriptionCell, 1991
- Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogasterNature, 1981
- The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programmeProceedings of the Royal Society of London. B. Biological Sciences, 1979
- Mutants of the Visual Pathway of Drosophila melanogasterNature, 1970
- Building a Bacterial VirusScientific American, 1967