Tissue Factor: An Enzyme Cofactor and a True Receptor
- 1 January 2001
- journal article
- research article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 86 (07) , 66-74
- https://doi.org/10.1055/s-0037-1616202
Abstract
Tissue factor is considered to be the physiologic trigger of the blood clotting system in normal hemostasis and in many – perhaps most – thrombotic diseases. A wealth of new knowledge is available regarding the structure and assembly of the TF:VIIa complex and the role of factor VIIa and tissue factor in hypercoagulable states. The exciting recent finding that tissue factor can function as a signaling receptor, and suggestions that tissue factor may have important, non-hemostatic roles, will be the subject of much additional study in the near future.Keywords
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