INTERACTION OF DAUNOMYCIN WITH MEIOTIC CHROMOSOMES IN VICIA FABA

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Abstract
Daunomycin interferes with the meiotic cycle and structural integrity of chromosmes if administered to microsporocytes of Vicia faba during the meiotic prophase substages prior to diplotene. The principal cytological consequences of daunomycin treatment are as follows: induced achromatic lesions, chromosome fragmentation, terminal and interstitial deletions, loose or non-pairing regions, multivalent associations, reduced chromosome condensation, chromosome stickiness, dicentric and side-arm bridges and chromatid loops. A correlation between inhibition of DNA or RNA and the cytological manifestation of structural anomalies or unfolding of meiotic events is discussed.