TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF‐κB activation
- 30 May 2002
- journal article
- Published by Wiley in FEBS Letters
- Vol. 521 (1-3) , 165-169
- https://doi.org/10.1016/s0014-5793(02)02869-7
Abstract
Proteins containing the caspase recruiting domain (CARD) have emerged as critical regulators of different signal transduction pathways, including those controlling apoptosis and activation of necrosis factor (NF)‐κB transcription factor. TUCAN/CARDINAL is a recently identified CARD‐containing protein involved in regulation of caspases and NF‐κB activation. We find that TUCAN/CARDINAL associates with DRAL, a p53‐responsive gene implicated in induction of apoptosis. We also show that, whereas TUCAN/CARDINAL exerts a suppressive effect on NF‐κB activity, expression of DRAL results in enhancement of NF‐κB activation. Thus, our observations suggest that DRAL and TUCAN/CARDINAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF‐κB transcription factor.Keywords
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