The HBZ gene, a key player in HTLV-1 pathogenesis
Open Access
- 3 August 2009
- journal article
- review article
- Published by Springer Nature in Retrovirology
- Vol. 6 (1) , 71
- https://doi.org/10.1186/1742-4690-6-71
Abstract
Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ) gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis.Keywords
This publication has 42 references indexed in Scilit:
- Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense Transcription by the Viral Tax ProteinJournal of Virology, 2009
- Human T-cell Leukemia Virus Type 1 HBZ Protein Bypasses the Targeting Function of UbiquitinationJournal of Biological Chemistry, 2008
- Transcriptional Control of Spliced and Unspliced Human T-Cell Leukemia Virus Type 1 bZIP Factor ( HBZ ) GeneJournal of Virology, 2008
- An Interaction between the Human T Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) and the KIX Domain of p300/CBP Contributes to the Down-regulation of Tax-dependent Viral Transcription by HBZJournal of Biological Chemistry, 2008
- Cooperation of NF-κB2/p100 Activation and the PDZ Domain Binding Motif Signal in Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax1 but Not HTLV-2 Tax2 Is Crucial for Interleukin-2-Independent Growth Transformation of a T-Cell LineJournal of Virology, 2007
- Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple MyelomaCancer Cell, 2007
- Detection and quantitation of HTLV-1 and HTLV-2 mRNA species by real-time RT-PCRJournal of Virological Methods, 2007
- Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 TranscriptionJournal of Virology, 2007
- The role of NF-κB-1 and NF-κB-2-mediated resistance to apoptosis in lymphomasProceedings of the National Academy of Sciences, 2006
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980