ACUTE INFECTIOUS LYMPHOCYTOSIS: A SPECIFIC INFECTION

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Abstract
In 1941 I reported the cases of 2 young children who, with a minimum of clinical signs and symptoms, showed an unexpected and exaggerated lymphocytosis, with maximum leukocyte counts of 44,300 and 98,000 per cubic millimeter, respectively.1These cases were described in conjunction with those of a larger group of children with more moderate and prolonged lymphocytic reactions, which are more frequently encountered in pediatric practice. For these two types of blood conditions the terms acute and chronic infectious lymphocytosis, respectively, were suggested. The two forms of infectious lymphocytosis were differentiated clinically, hematologically and serologically from infectious mononucleosis, acute lymphatic leukemia and miscellaneous infections associated with lymphocytosis. During March 1943, within a period of three weeks, 4 cases of acute infectious lymphocytosis were again observed at the New York Hospital. The fact that 3 of the patients were members of one family and 1 a hospital contact indicated that

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