SPECIFIC THERAPY OF BACTERIAL INFECTIONS OF CENTRAL NERVOUS SYSTEM

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Abstract
Therapeutic agents are now available to combat most bacterial infections of the central nervous system. Consequently, proper treatment depends on (1) prompt diagnosis of the disease, (2) prompt determination of the etiologic agent and (3) selection of the appropriate drug or antibiotic. Since such selection depends on the causative organism in any given case, we have arranged the present discussion according to the bacteria responsible for the various diseases. MENINGITIS CAUSED BY GRAM-NEGATIVE COCCI Meningococcic Meningitis.— Meningococcic meningitis is the most frequent type of meningitis. Excellent results have been obtained with sulfadiazine or sulfamerazine. The dose for adults is 6 Gm. immediately and 1 Gm. every four hours and for children 70 mg. per kilogram (1/2 grain per pound) of body weight immediately and 150 mg. per kilogram (1 grain per pound) for each twenty-four hours thereafter, at four hour intervals. Comatose patients should be