CRYSTALLIZATION OF CALCIUM-OXALATE FROM SYNTHETIC URINE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 15  (6) , 469-472
Abstract
Precipitation of calcium oxalate from synthetic urine was followed from the disappearance of radioactive oxalate from solution. Rates of precipitation were estimated from the time of appearance of crystals. Synthetic urine inhibited the rate of crystallization of calcium oxalate; this inhibition was a combined effect of ionic strength and specific inhibition by 1 or more components of the synthetic urine. Polyphosphate and polyacrylate ions strongly inhibited crystallization of calcium oxalate from synthetic urine; phosphonates, heparin and polystyrene sulfonate showed much less inhibition. Inasmuch as citrate and pyrophosphate ions showed some inhibition, it seems that carboxylate and phosphate groups on a polymer chain are the most effective inhibitors. [Renal stone disease in humans was discussed.].