Modification of Titanium Electrodes for Detection of Biological Substances

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Abstract
Several modifications of the surface structure and texture of electrode substrate (titanium) were carried out by the treatments of rolling, heating, and ion bombardment to develop electrodes to detect biological substances. These electrodes were chemically modified with trypsin or aprotinin (trypsin inhibitor). The electric response measured in a specific reaction system of trypsin‐aprotinin depended on the characteristics of surface of the electrode substrate as well as the concentration of the biological substances. The ion bombardment in vapor was found to be more effective in modifying electrodes for biosensors of this type.

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