Mechanistic switch leading to highly efficient chirality transfer in Pd(0)-catalyzed coupling–cyclization of aryl iodides with 1∶1 acid–base salts of 2,3-allenoic acids and L-(−)-cinchonidine or D-(+)-/L-(−)-α-methylbenzylamine. Enantioselective synthesis of highly optically active 3-aryl polysubstituted butenolides
- 13 February 2002
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 5,p. 540-541
- https://doi.org/10.1039/b109645a
Abstract
An efficient methodology provides an easy access to highly optically active polysubstituted butenolides starting from aryl halides and 1:1∶salts of optically active 2,3-allenoic acid–base via an oxidative addition–coordinative cyclization–reductive elimination mechanism, which led to the high efficiency of this chirality isomerization reaction.Keywords
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