What's the point of the type III secretion system needle?
- 6 May 2008
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 105 (18) , 6507-6513
- https://doi.org/10.1073/pnas.0708344105
Abstract
Recent work by several groups has significantly expanded our knowledge of the structure, regulation of assembly, and function of components of the extracellular portion of the type III secretion system (T3SS) of Gram-negative bacteria. This perspective presents a structure-informed analysis of functional data and discusses three nonmutually exclusive models of how a key aspect of T3SS biology, the sensing of host cells, may be performed.Keywords
This publication has 70 references indexed in Scilit:
- Differences in the Electrostatic Surfaces of the Type III Secretion Needle Proteins PrgI, BsaL, and MxiHJournal of Molecular Biology, 2007
- Structure of the heterotrimeric complex that regulates type III secretion needle formationProceedings of the National Academy of Sciences, 2007
- Protein secretion systems and adhesins: The molecular armory of Gram-negative pathogensInternational Journal of Medical Microbiology, 2007
- Bile Salts Stimulate Recruitment of IpaB to the Shigella flexneri Surface, Where It Colocalizes with IpaD at the Tip of the Type III Secretion NeedleInfection and Immunity, 2007
- Self-chaperoning of the Type III Secretion System Needle Tip Proteins IpaD and BipDPublished by Elsevier ,2007
- The type III secretion injectisomeNature Reviews Microbiology, 2006
- Protein delivery into eukaryotic cells by type III secretion machinesNature, 2006
- Molecular model of a type III secretion system needle: Implications for host-cell sensingProceedings of the National Academy of Sciences, 2006
- IpaD Localizes to the Tip of the Type III Secretion System Needle of Shigella flexneriInfection and Immunity, 2006
- Contribution of Salmonella typhimurium type III secretion components to needle complex formationProceedings of the National Academy of Sciences, 2000