Assignment of genes to regions of mouse chromosomes.
Open Access
- 1 February 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (2) , 946-950
- https://doi.org/10.1073/pnas.75.2.946
Abstract
A genetic mapping procedure, called the duplication-deficiency method, is described. This method permits the genetic location of a translocation to be determined within a linkage group without the use of recombination. By utilizing the duplication-deficiency method to define the genetic breakpoints for a series of translocations involving a given chromosome and integrating this information with their cytological breakpoints, obtained by Giemsa banding, a genetic map of the chromosomes is constructed whereby groups of loci are assigned to banded regions. Duplication-deficiency mapping and Giemsa banding analysis of the T(X;7)1Ct and T(7;19)45H translocations together with information from the c25H deletion have permitted mouse [Mus musculus] chromosome 7 to be divided into 6 and chromosome 19 into 2 definable genetic regions.This publication has 28 references indexed in Scilit:
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