INFLUENCE OF PRESERVATION TIME ON OUTCOME AND METABOLIC FUNCTION OF BLADDER-DRAINED PANCREAS TRANSPLANTS

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Abstract
The influence of cold storage preservation time on graft survival and metabolic function of pancreatic transplants was studied in 130 recipients of bladder-drained grafts (47 simultaneous with, 33 after, and 50 without a kidney transplant) between October 1, 1984 and May 1, 1989. The recipients were divided into four groups according to the preservation time: < 6 hr (n = 11), 6–12 hr (n = 24), 12–24 hr (n = 75), and > 24 hr (n = 20). Twenty-six grafts were procured by other transplant teams and sent to us. Silica gel fractionated plasma was used for preservation in 104 cases and the University of Wisconsin solution in 25 (1 in the < 6 hr, 2 in the 6–12 hr, 16 in the 12–24 hr, and 6 in the > 24 hr groups). The technical failure rate at 1 month was 13% (17 grafts), 1 (9%) in the < 6 hr, 5 (21%) in the 6–12 hr, 9 (12%) in the 12–24 hr, and 2 (10%) in the > 24 hr groups. At 1 month, 107 (82%) of the grafts were functioning, 10 (91%) in the < 6 hr, 18 (75%) in the 6–12 hr, 62 (83%) in the 12–24 hr and 17 (85%) in the > 24 hr groups, the longest preserved for 30 hr. The respective 1-year graft survival rates were 51%, 50%, 57%, and 70%. Ninety patients (10 in the < 6 hr, 16 in the 6–12 hr, 51 in the 12–24 hr, and 13 in the > 24 hr groups) had metabolic studies between 2 and 6 weeks posttransplant. The results of 24-hour profiles (14 blood glucose determinations) were similar in each preservation time group; the means of the mean (±SD) profile glucose (mg/dl) values were 130±19, 126±31, 130±24, and 129±30, respectively (P > 0.6). Mean plasma glucose levels at 2 hr during OGTT were 141±32, 145±43,

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