Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies
- 1 January 2003
- journal article
- Published by Springer Nature in The Cerebellum
- Vol. 2 (1) , 77-79
- https://doi.org/10.1080/14734220309432
Abstract
Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.Keywords
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