Minimisation of salicylic acid formation during preparation of aspirin products for analysis by high-performance liquid chromatography
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 109 (10) , 1327-1329
- https://doi.org/10.1039/an9840901327
Abstract
The simultaneous separation of aspirin and its degradation product salicylic acid, together with caffeine and paracetamol, can be achieved by reversed-phase high-performance liquid chromatography. The accuracy of measurement of salicylic acid is reduced by conversion of aspirin into salicylic acid during sample preparation. This is a serious limitation when other components of aspirin preparations, such as carbonates, catalyse the conversion or when sample solutions are prepared in advance for use with an autoinjector. A sample solvent containing acetic anhydride, oxalic acid and acetic acid has been found to reduce hydrolysis to about 5% of that of a conventional solvent (methanol).Keywords
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