Source and distribution of factors in locust nervous system which stimulate rectal Cl− transport

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Abstract
Corpus cardiacum (CC) of locusts contains a potent stimulant of rectal Cl transport, i.e., chloride transport stimulating hormone (CTSH). Extracts of other locust tissues which contain neuroendocrine cells were assayed for their ability to stimulate Cl-dependent, short-circuit current (Isc) across recta mounted in Ussing chambers. Dose–response curves indicated that only brain (particularly the pars intercerebralis, PI) contained substantial stimulatory activity, but this was still at very low concentrations compared with CTSH activity in CC. Destruction of either the PI or the nerve tract from PI to CC (i.e., NCC I) reduced CTSH levels in the CC. In contrast, destruction of lateral neurosecretory cells (NSCs) of the brain had no effect. The results suggest that CTSH is synthesized in NSCs of the PI and is transported down NCC I to the CC where it may mature to a more active form.

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