The Prospect of Silencing Disease Using RNA Interference
- 16 March 2005
- journal article
- review article
- Published by American Medical Association (AMA) in JAMA
- Vol. 293 (11) , 1367-1373
- https://doi.org/10.1001/jama.293.11.1367
Abstract
The discovery of RNA interference (RNAi), an endogenous cellular gene-silencing mechanism, has already provided a powerful tool for basic science researchers to study gene function. The subsequent finding that RNAi also operates in mammalian cells has generated excitement regarding potential therapeutic applications. In this article we discuss the basic mechanism of RNAi and the therapeutic opportunities and obstacles for harnessing RNAi for therapy of human disease.Keywords
This publication has 1 reference indexed in Scilit:
- Gene Silencing by Systemic Delivery of Synthetic siRNAs in Adult MiceJournal of Molecular Biology, 2003